NIPT and Cell-free DNA screening in twin pregnancies

NIPT White Papers

Cell-Free DNA Screening in Twin Pregnancies
 

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Pregnancies with more than one fetus are not uncommon. According to 2018 data, almost 1 in 30 babies born are of a twin pregnancy.1 Infants born from a pregnancy with multiples are at a higher risk for adverse outcomes including birth defects, low-birth weight and preterm deliveries, and therefore, professional societies around the world recommend increased surveillance and screening for these pregnancies.2–7

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References

  1. Martin JA, Osterman MJK. Is Twin Childbearing on the Decline? Twin Births in the United States 2014-2018 NCHS Data Brief No 351, October 2019
  2. Centre NC. Multiple pregnancy. Heal (San Fr. 2011;(September).
  3. ACOG. Practice Bulletin 169: Multifetal gestations: Twin, triplet and higherorder multifetal pregnancies. Obstet Gynecol. 2016;128(4):e131-e146.
  4. Oepkes D, Sueters M. Antenatal fetal surveillance in multiple pregnancies. Best Pract Res Clin Obstet Gynaecol. 2017;38:59-70.
  5. Khalil A, Rodgers M, Baschat A, et al. ISUOG Practice Guidelines: role of ultrasound in twin pregnancy. Ultrasound Obstet Gynecol. 2016;47(2):247- 263.
  6. American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine. Obstetric Care Consensus No. 6. Obstet Gynecol. 2017;130(4):e187-e199.
  7. Audibert F, Gagnon A. No. 262-Prenatal Screening for and Diagnosis of Aneuploidy in Twin Pregnancies. J Obstet Gynaecol Canada. 2017;39(9):e347-e361.

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The Harmony Prenatal Test is a non-invasive prenatal test (NIPT) based on cell-free DNA analysis and is considered a prenatal screening test, not a diagnostic test. Harmony does not screen for potential chromosomal or genetic conditions other than those expressly identified here. All women should discuss their results with their healthcare provider, who can recommend confirmatory, diagnostic testing where appropriate. The Harmony Prenatal Test was developed, and its performance characteristics determined by Ariosa Diagnostics, Inc., a CLIA-certified and CAP-accredited clinical laboratory in San Jose, CA USA. This testing service has not been cleared or approved by the US FDA.
HARMONY is a trademark of Roche. All other product names and trademarks are the property of their respective owners.

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Last Updated: 03/04/2021