Positive Predictive Value (PPV) – White Paper

NIPT White Papers

Positive Predictive Value and Interpretation of Results of the Harmony® Prenatal Test
 

Download the White Paper

 


Education and the appropriate clinical interpretation of results are identified challenges for the widespread implementation of fetal aneuploidy screening using cell-free DNA analysis. Some thought leaders propose that positive predictive value (PPV) may be a useful concept for both education and counseling. It is important to recognize that PPV is a statistical measure within the context of a population and that there are limitations to applying it individually. Theoretical PPV and NPV calculations based on estimated pre-test risk and published test performance may provide a foundation for discussion and setting expectations regarding the significance of screening results and may assist patients in decision-making regarding diagnostic testing. However, this information should be interpreted with caution and an understanding of its limitations. Ultimately, all risk assessment must be considered within the broader clinical picture.

Download the White Paper