NIPT & Chromosomal Conditions
Non-invasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) derived from the pregnancy to evaluate possible chromosomal conditions in a pregnancy.
Why screen for chromosomal conditions?
Chromosomal conditions such as Down syndrome can happen in any pregnancy - even when there is no family history - because they typically are not inherited. They happen by "chance," and although the chance increases with mother's age, most babies with chromosomal conditions are born to women under 35 years of age.1
That’s why the American College of Obstetricians and Gynecologists (ACOG) recommends that all pregnant women be offered screening and diagnostic tests for chromosomal conditions.2 And since NIPT is the most sensitive screening option for trisomy 21, 18, and 13, the International Society for Prenatal Diagnosis (ISPD) supports offering NIPT to all pregnant women.3
Your prenatal screening results can provide you and your doctor with information specific to your pregnancy so you can have more informed conversations about your prenatal care.
The Harmony Test
Chromosomal conditions can occur in any pregnancy. The Harmony prenatal test screens for the most common ones, including:
- Trisomy 21 (Down syndrome), trisomy 18 and trisomy 13
- 22q11.2 microdeletion
- Monosomy X
- Sex chromosome aneuploidies (SCA)
- The California Prenatal Screening Program. March 2009. Provider Handbook 2009.
- ACOG Practice Bulletin 163 Obstet Gynecol. 2016 May;127(5):e123-37.
- Benn et al. Prenat Diagn 2015; 35: 725–734.